BASF combines economic success with environmental protection and social responsibility. Around 112,000 employees in the BASF Group contribute to the success of our customers in nearly all sectors and almost every country in the world. Our portfolio comprises six segments: Chemicals, Materials, Industrial Solutions, Surface Technologies, Nutrition & Care and Agricultural Solutions.
At BASF, we create chemistry for a sustainable future.
BASF contributes to societal progress and environmental protection by designing functional, costeffective, safe, and sustainable products. We invest in research and development to meet
consumer needs through innovative solutions.
At BASF, the development of SSbD principles has been a gradual process that dates to the company’s inception. SSbD requires considering various dimensions, including occupational safety, consumer safety, environmental safety, and overall sustainability, assessed through Life Cycle Analysis-based methods.
The need for occupational safety was so evident to BASF that it became a focus shortly after the company’s founding. Since 1908, BASF has been conducting toxicological investigations.
BASF’s Experimental Toxicology & Ecology develops, validates and applies testing strategies to evaluate the potential toxicity and ecological impact of anything BASF produces including industrial chemicals and plant protection products. In addition to applying rigorous existing testing protocols, BASF’s Experimental Toxicology & Ecology develops and validates new approach methodologies (NAMs) to improve the quality and reliability of our testing strategies. The department is dedicated to animal welfare and actively promotes research to advance the use of alternative, animal-free methods.
BASF’s role in CHIASMA
CHIASMA’s overarching objective is to devise and demonstrate a comprehensive set of NAMs and integrate them into a user-friendly, reliable, and robust framework to perform human and environmental safety evaluations in a regulatory context.
BASF will select NAMs developed in CHIASMA to study methods’ transferability and knowledge transfer towards industrial scenarios. These scenarios present unique requirements, operations,
licensing, and other aspects. The selected methods will be implemented at BASF premises, following knowledge and technological transfer, to be tested against selected biological endpoints with reference chemicals.
To achieve regulatory acceptance, the optimized method description can be used to develop a standard, either at OECD or ISO. These tests will be further developed, recognizing GLP and GIVIMP. An outline will be provided on how to interpret the outcomes concerning Next Generation Safety and Risk Assessment (NGSA; NGRA) as well as classification and labeling schemes.
