Accessible Innovative Methods for the Safety & Sustainability Assessment of Chemicals & Materials

CHIASMA's Vision

The CHIASMA Project will devise and demonstrate a comprehensive set of New Approach Methodologies (NAMs) and integrate them in a user friendly, reliable and robust framework to perform human and environmental safety evaluation in a regulatory context.  

CHIASMA's R&I Approach

Illustration of the CHIASMA R&I approach to testing and assessment of materials using an iterative approach based on the integration of (1) chemocentric, (2) biocentric and (3) new experimental models into a conceptual framework for data-integration and -processing.

CHIASMA's Policy Aligment

The CHIASMA Project is fully aligned with the EU strategies for the development of the Safe and Sustainable by Design (SSbD) framework to ensure safety and sustainability of enabling and emerging technologies ⎼ including those based on chemicals and materials, as addressed in the EU’s Chemical Strategy for Sustainability (2020), in the European Green Deal (2021) and in the Advanced Materials 2030 Initiative (AMI2030). CHIASMA will focus on developing New Approach Methodologies (NAMs) and improved Life Cycle Impact Assessment (LCIA) approaches and strategies, to ultimately integrate these into the CHIASMA Framework for the combined assessment of Safe & Sustainable by Design (SSbD) to support REACH (regulation for the Registration, Evaluation, Authorisation and Restriction of Chemicals), CLP (regulation for Classification, Labelling and Packaging of chemicals) and other relevant regulations, such as the (proposed) Ecodesign for Sustainable Products Regulation and the EU Ecolabel regulation.

In CHIASMA the term ‘material’ means ‘Advanced Materials’ (AdMas), since it includes and surpasses that of ‘nanomaterials’ (EU, ‘Definition of a Nanomaterial’); in this, the Project is aligned with the future-oriented innovation, safety and sustainability considerations of the OECD (OECD (2020a); OECD (2020b)), the EU (EU (2022)), and Member States (e.g., Germany (2021)).

CHIASMA's High-Level Objectives

Interface Communities and ensure regulatory relevance of NAMs to assess the safety of chemicals/materials.

Demonstrate the usefulness of NAMs for the implementation of REACH and CLP regulations.

Develop NAMs and validate them for the regulatory assessment of long-term safety.

Develop and user-stress-test software interface and insurance of proper handling by authorities, regulators and end users.

Demonstrate the transferability of the CHIASMA’s NAMs.

Demonstrate the trans-domains applicability of the CHIASMA’s safety and environmental framework.

Improve the Life Cycle Impact Assessment model for human toxicity and ecotoxicity.

FAIR-ification and GLP-ification of protocol and methods.